From Closed Doors to Open Roads: A Teacher’s Victory Over SCLC Without Targeted Therapy

For every patient who travels a long distance to seek our care, we deeply understand: what you bring is not only complex medical records but also the trust and hopes of your entire family.

At the Beijing South Region Oncology Hospital International Department, we witness such stories every day—how our doctors stand shoulder to shoulder with patients when one treatment path is temporarily closed, finding another open road leading to hope.

A Chinese Teacher’s Choice: When “No Targeted Therapy” Is No Longer the End】

In early autumn 2025, 68-year-old Teacher Liu only felt a dull pain in his left chest. Two months later, a CT report brought the unfamiliar and heavy term “small cell lung cancer” into this ordinary teacher’s family. Even more distressing was the genetic test result: no driver gene mutation corresponding to targeted therapy drugs was identified.

At many medical institutions, this might mean “the window for targeted therapy is closed.” However, at Beijing South Region Oncology Hospital, the attending physician Dr. Zhang Wei told Teacher Liu and his daughter Liu Jing: “This by no means indicates that no effective drugs are available. On the contrary—it helps us avoid detours and directly focus on the ‘main highway’ that is currently the most effective, well-established, and full of hope.”

Now, Teacher Liu’s treatment has achieved results beyond expectations. His story is becoming a shared reference for an increasing number of international patients.

Our “Combined Strategy”: When Mainstream Regimens Are Perfected, They Become the Frontier】

Hyperthermia + Radiotherapy: 1+1 > 2 Synergistic Sensitization

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Of Teacher Liu’s 28 radiotherapy sessions, 20 were closely combined with regional radiofrequency hyperthermia.

Synergistic Sensitization: Hyperthermia disrupts the protein structure of cancer cells and inhibits their DNA repair capacity, making them more sensitive to radiation. The combination achieves a “1+1>2” local therapeutic effect.

● Strong Targeted Effect: Particularly suitable for cases like Teacher Liu’s with rib bone destruction. Hyperthermia can more effectively target bone tissue and surrounding tumors, often providing good outcomes in relieving bone pain and controlling local progression.

● Paving the Way for Subsequent Treatment: Through this powerful local therapy, the tumor burden is minimized to the greatest extent, allowing any potential micrometastases in other parts of the body to be better controlled during subsequent systemic treatments (such as follow-up chemotherapy or maintenance immunotherapy). This also provides a stronger rationale and higher safety for the decision to perform cryoablation on residual primary lesions.

What were the results? Teacher Liu’s follow-up imaging showed significant regression of the primary lesion and a substantial reduction in tumor burden.

This is not an isolated case. At our hospital, the synergistic application of hyperthermia and radiotherapy has become a standard intensification approach for locally advanced solid tumors such as lung cancer, pancreatic cancer, and soft tissue sarcomas.

Why Choose Beijing South Region Oncology Hospital International Department?】

1. Not “Fighting Alone,” But “Team Consultation”

In Teacher Liu’s case, we saw:

- Medical Oncology devising maintenance immunotherapy strategies

- Radiation Oncology collaborating with the hyperthermia team to implement sensitizing radiotherapy

- Interventional Radiology assessing the timing for cryoablation

- Pathology and Radiology providing full-course quality control

Every patient is supported by a multidisciplinary team.

2. Not “Just Having Drugs,” But “Comprehensive Planning”

We never merely answer “What’s next?” Instead, we co-draw with you:

- The core plan for the current stage

- Alternative pathways to address resistance/progression

- Future accessible clinical trial opportunities

Layered treatment, graded hope.

3. Not a “Single Path,” But a “Combined Strategy”

The success of Teacher Liu’s treatment was not due to a single “miracle therapy,” but rather:

Chemotherapy as a foundation → Hyperthermia-sensitized radiotherapy → Maintenance immunotherapy for consolidation → Local ablation for intensification

This is a highly integrated, interlocking comprehensive treatment plan. At Beijing South Region Oncology Hospital, we do not rely on a “single knockout punch”; we believe in “systematic combat.”

No matter what stage of treatment you are in, we are willing to conduct a preliminary remote medical record review for you.

Contact Us

Beijing South Region Oncology Hospital International Department

Hotline: 400-880-3716

WeChat: 17801183037

Email:

100085_010@163.com

myimmnet@163.com

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Post time: Feb-12-2026